The EVP/VP of Medicinal Chemistry will be responsible for all chemistry activities within drug discovery including compound screening, SAR studies, hit-to-lead activities, and lead optimization.
Roles and responsibilities include the following:
Provide vision and leadership for the identification of novel small molecule modulators of RNA processes
Lead the assessment and progression of potential small molecule drugs from screening to hits and leads to clinical candidate
Identify, evaluate, support, and manage pre-clinical chemistry drug discovery activities with CROs
Travel as necessary to establish and manage key relationship at CROs and partner labs
Lead and manage drug discovery programs based on quality, time, budgets, and resources.
Manage, evaluate, and maintain critical data in a highly organized and accessible manner. Provide appropriate reports and updates to management and ensure achievement of project and company goals
Function as part of a multi-disciplinary team and coordinate with others, i.e. screening, biology, ADME/PK, etc., to advance drug discovery programs
Produce scientific proposals, progress reports, and grant applications to support program and company goals
Ensure that IP assets are developed, managed, and protected
Provide scientific input and leadership in strategic discussions with company leadership and external advisors
Qualified candidates will have the following requirements and experience:
Ph.D. or equivalent in relevant chemistry discipline along with 10-15+ years of experience in a small molecule drug discovery setting within a biotechnology or pharmaceutical company
Established record of success as a medicinal chemistry group leader within a drug discovery setting
Demonstrated experience and success in identifying and managing medicinal chemistry research with CROs
Track record of high ethical standards, trustworthiness, and personal responsibility
Advanced written and oral communication skills with an ability to eloquently present complex strategies and results to influence scientific direction to achieve program and company goals
Superior project management skills
Demonstrated effectiveness in team settings with a willingness to openly share ideas and expertise
Ability to develop and execute IP strategies in conjunction with legal counsel to ensure protection of company assets.
Experience as a PI on SBIR or other grants preferred.
Telecommuting is allowed.
About MS2 Array LLC
MS2 Array is a startup drug discovery company located in Pittsburgh, PA. Our mission is to discovery innovative new small molecule therapies that target clinically relevant RNA molecules using our patented high-throughput mass spectrometry based screening platform.
Our technology has been validated through a pilot project with a major pharma company, the granting of a US patent with a second pending, and the awarding of an NIH SBIR research grant. At this time we are looking to build out our capabilities and expertise with an eye toward hiring experienced researchers with an established track record of success in small molecule drug discovery.